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Home » Estrogen & Hormones » Oestrogel

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Buy Oestrogel


Brand Names: Osestrogel, Estrogel
Generic Name:
Manufacturer: Laboratoiers Besins International

How does it work?
Oestrogel contains the active ingredient estradiol (previously spelt oestradiol in the UK), which is a naturally occuring form of the main female sex hormone, oestrogen.

Womens’ ovaries gradually produce less and less oestrogen in the period up to the menopause, and oestrogen blood levels decline as a result. The declining levels of oestrogen can cause distressing symptoms, such as irregular periods, hot flushes, night sweats, mood swings and vaginal dryness or itching.

Oestrogen (in this case in the form of estradiol) can be given as a supplement to replace the falling levels in the body and help reduce these distressing symptoms of the menopause. This is known as hormone replacement therapy (HRT). HRT is usually only required for short-term relief from menopausal symptoms and its use should be reviewed at least once a year with your doctor.

Oestrogel is an oestrogen-only form of HRT. The gel is applied to the skin and the estradiol is absorbed through the skin into the bloodstream.

As it only contains oestrogen, Oestrogel can be used on its own by women who have had a hysterectomy. Women who have not had a hysterectomy should also be prescribed a progestogen medicine to take with this medicine, for the last 12 to 14 days of each month. This is because oestrogen stimulates the growth of the womb lining (endometrium), which can lead to endometrial cancer if the growth is unopposed. A progestogen is given to oppose oestrogen's effect on the womb lining and reduce the risk of cancer, though it does not eliminate this risk entirely. This is known as combined HRT. If a woman has had her womb surgically removed (a hysterectomy), endometrial cancer is not a risk, and a progestogen is not necessary as part of HRT (unless the woman has a history of endometriosis).

HRT is also sometimes used to prevent osteoporosis in postmenopausal women. The declining level of oestrogen at menopause can affect the bones, causing them to become thinner and more prone to breaking. Oestrogen supplements help prevent bone loss and fractures that may occur in women in the years after menopause.

However, in December 2003, a review of the available evidence on the risks and benefits of HRT by the Medicines and Healthcare products Regulatory Agency (MHRA) and the Committee on Safety of Medicines (CSM) in the UK, concluded that the risks of using HRT long-term to prevent osteoporosis in women aged over 50 years exceed the benefits. As a result this medicine should not be used as a first-line option for preventing postmenopausal osteoporosis in women over 50. However, it may be used as a second-line option for women at high risk of fractures who cannot take other medicines that are licensed for this purpose.

Women considered to be at risk of developing fractures following the menopause include those who have had an early menopause, those with a family history of osteoporosis, those who have had recent prolonged corticosteroid therapy (eg prednisolone), those with a small thin frame, and smokers.

You can read more about the risks and benefits of HRT and other medicines for preventing osteoporosis in the factsheets about menopause and osteoporosis linked below.

What is it used for?
Hormone replacement therapy to relieve symptoms of the menopause

Second-line option for preventing osteoporosis in postmenopausal women who are at high risk of fractures and cannot take other medicines licensed for preventing osteoporosis

Follow the instructions provided with your Oestrogel carefully. Oestrogel should be applied each day to a clean, dry, unbroken, non-irritated area of skin on the arms, shoulders or inner thighs. The area of skin used for applying the gel should be twice that of the template provided with the medicine. The gel should NOT be applied on or near the breasts, vaginal area or face. Avoid contact of the gel with your eyes. Wash your hands after applying the gel. After applying the gel let it dry for a few minutes before dressing and do not wash the area, or apply other skin products (eg creams, lotions, powders) to the area for at least one hour. Avoid skin contact with another person (particularly male) for at least an hour after applying the gel.

Women using any form of HRT should have regular medical and gynaecological check-ups. Your need for continued HRT should be reviewed with your doctor at least once a year.

It is important to be aware that all women using HRT have an increased risk of being diagnosed with breast cancer compared with women who don't use HRT. This risk needs to be weighed against the personal benefits to you of using HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. You should discuss these with your doctor before starting HRT. Women on HRT should have regular breast examinations and mammograms and should examine their own breasts regularly. Report any changes in your breasts to your doctor or nurse.

  • It is important to be aware that women using HRT have a slightly increased risk of stroke and of blood clots forming in the veins (eg deep vein thrombosis/pulmonary embolism) compared with women who don't use HRT. The risk is higher if you have existing risk factors (eg personal or family history, smoking, obesity, certain blood disorders - see cautions below) and needs to be weighed against the personal benefits to you of taking HRT. There is more detailed information about the risks and benefits associated with HRT in the factsheet about the menopause linked above. Discuss these with your doctor before starting treatment.

  • The risk of blood clots forming in the veins (thromboembolism) while using HRT may be temporarily increased if you experience major trauma, have surgery, or are immobile for prolonged periods of time (this includes travelling for over five hours). For this reason, your doctor may recommend that you stop taking HRT for a period of time (usually four to six weeks) prior to any planned surgery, particularly abdominal surgery or orthopaedic surgery on the lower limbs, or if you are to be immobile for long periods. The risk of blood clots during long journeys may be reduced by appropriate exercise during the journey and possibly by wearing elastic hosiery. Discuss this with your doctor.

  • Stop using this medicine and inform your doctor immediately if you experience any of the following symptoms while using this medicine: stabbing pains or swelling in one leg; pain on breathing or coughing; coughing up blood; breathlessness; sudden chest pain; sudden numbness affecting one side or part of the body; fainting; worsening of epilepsy; migraine or severe headaches; visual disturbances; severe abdominal complaints; increased blood pressure; itching of the whole body; yellowing of the skin or eyes (jaundice); or severe depression.

  • This medicine will not usually cause a monthly withdrawal bleed, unless you are also prescribed progestogen tablets to take for the last few days of each month. However, you may experience spotting or breakthrough bleeding during the first few months of treatment. Missing a daily application of the gel may increase the likelihood of bleeding. If any breakthrough bleeding or spotting continues after a few months of taking the medicine, or after stopping treatment, you should consult your doctor.

  • A woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. HRT does not provide contraception for women who fall within this group. If a potentially fertile women is taking HRT but also requires contraception, a non-hormonal method (eg condoms or contraceptive foam) should be used.

Use with caution in
Close family history of breast cancer (eg mother, sister or grandmother has had the disease)
History of benign breast lumps (fibrocystic breast disease)
History of fibroids in the womb
History of endometriosis
History of overgrowth of the lining of the womb (endometrial hyperplasia)
Personal or family history of blood clots in the veins (venous thromboembolism, eg deep vein thrombosis or pulmonary embolism)
Blood disorders that increase the risk of blood clots in the veins, eg antiphospholipid syndrome, factor V Leiden
Women taking medicines to prevent blood clots (anticoagulants), eg warfarin
Long-term inflammation of skin and some internal organs (systemic lupus erythematosus)
Personal or family history of recurrent miscarriage
Severe obesity
Varicose veins
History of high blood pressure (hypertension)
Raised levels of fats called triglycerides in the blood (hypertriglyceridaemia)
History of liver disease, eg liver cancer
Decreased kidney function
Heart failure
History of diabetes
History of gallstones
History of migraines or severe headaches
History of epilepsy
History of asthma
History of an ear disorder that may cause hearing loss (otosclerosis)
History of irregular brown patches appearing on the skin, usually of the face, during pregnancy or previous use of hormone preparations such as contraceptive pills (chloasma). Women with a tendency to this condition should minimise their exposure to the sun or UV light while taking HRT.

Not to be used in
Known, suspected, or past history of breast cancer
Known or suspected cancer in which growth of the cancer is stimulated by oestrogen, eg cancer of the lining of the womb (endometrial cancer)
Untreated overgrowth of the lining of the womb (endometrial hyperplasia)
Vaginal bleeding of unknown cause
Women with a blood clot in a vein of the leg (deep vein thrombosis) or in the lungs (pulmonary embolism), or a past history of these conditions where the cause is unknown
Women who have recently had a stroke caused by a blood clot
Women who have recently had a heart attack
Angina pectoris
Active liver disease
History of liver disease when liver function has not returned to normal
Hereditary blood disorders known as porphyrias

This medicine should not be used if you are allergic to one or any of its ingredients. Please inform your doctor or pharmacist if you have previously experienced such an allergy.

If you feel you have experienced an allergic reaction, stop using this medicine and inform your doctor or pharmacist immediately.

Pregnancy and Breastfeeding
Certain medicines should not be used during pregnancy or breastfeeding. However, other medicines may be safely used in pregnancy or breastfeeding providing the benefits to the mother outweigh the risks to the unborn baby. Always inform your doctor if you are pregnant or planning a pregnancy, before using any medicine.

  • This medicine should not be used by women who are pregnant or breastfeeding. You should stop using this medicine and consult your doctor immediately if you get pregnant during treatment.

  • A woman is considered fertile for two years after her last menstrual period if she is under 50, or for one year if over 50. HRT does not provide contraception for women who fall within this group. If you could get pregnant while taking this HRT, you should use a non-hormonal method of contraception (eg condoms or contraceptive foam). Seek medical advice from your doctor.

Side effects
Medicines and their possible side effects can affect individual people in different ways. The following are some of the side effects that are known to be associated with this medicine. Because a side effect is stated here, it does not mean that all people using this medicine will experience that or any side effect.

  • Breast pain, tenderness or enlargement
  • Headache/migraine
  • Breakthrough bleeding and spotting
  • Gut disturbances, such as nausea, abdominal pain, bloating, flatulence, indigestion
  • Swelling of the ankles due to to fluid retention (peripheral oedema)
  • Weight gain
  • Skin irritation at application site
  • Changes in sex drive
  • Depression
  • Anxiety
  • Premenstrual-like symptoms
  • Vaginal thrush
  • Rise in blood pressure
  • Dizziness
  • Gall bladder disease
  • Skin reactions such as rash and itch
  • Disturbance in liver function
  • Irregular brown patches on the skin, usually of the face (chloasma)
  • Blood clots in the blood vessels (eg, DVT, pulmonary embolism, heart attack, stroke - see warnings above)

The side effects listed above may not include all of the side effects reported by the drug's manufacturer.

For more information about any other possible risks associated with this medicine, please read the information provided with the medicine or consult your doctor or pharmacist.

How can this medicine affect other medicines?
It is important to tell your doctor or pharmacist what medicines you are already taking, including those bought without a prescription and herbal medicines, before you start treatment with this medicine. Similarly, check with your doctor or pharmacist before taking any new medicines while using this one, to ensure that the combination is safe.

The following medicines may potentially reduce the blood levels and effect of this medicine, which could result in recurrence of symptoms or irregular bleeding:

  • antiepileptic medicines such as carbamazepine, phenytoin, phenobarbital and primidone
  • barbiturates such as amobarbital
  • protease inhibitors for HIV infection such as ritonavir and nelfinavir
  • rifamycin antibiotics such as rifabutin and rifampicin
  • the herbal remedy St John's wort (Hypericum perforatum).

Oestrogens may increase the blood level of ropinirole used to treat Parkinson's disease.

Some women with diabetes may need small adjustments in their dose of insulin or antidiabetic tablets while using this medicine. You should monitor your blood sugar and seek advice from your doctor or pharmacist if your blood sugar control seems to be altered after starting this medicine.

News Update

September 7th, 2016:

October 26, 2015:
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