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Tri-Luma Cream

Brand Name: Tri-Luma Cream
Generic Name:
Fluocinolone, Hydroquinone, and Tretinoin topical
Manufacturer: Galderma

Tri-Luma® Cream is the only triple-action cream approved for the short-term and intermittent long-term treatment of moderate to severe melasma. The latest long-term safety studies confirm that Tri-Luma® Cream is safe and effective when used for longer than eight weeks and repeatedly thereafter when melasma recurs.

Tri-Luma's special combination of three active ingredients is more effective than any combination of the individual components in reducing the darkened skin caused by melasma.* Learn more about this treatment and ask your doctor if Tri-Luma® Cream is right for you.


Tri-Luma® Cream is contraindicated in individuals with a hypersensitivity, allergy or intolerance to fluocinolone acetonide, hydroquinone or tretinoin. In clinical trials, the most frequently reported side effects were erythema, desquamation, burning, dryness and pruritus.

Mild to moderate redness, peeling, burning, dryness or itching may be experienced. This product contains sulfites that may cause severe allergic reactions including anaphylactic symptoms and life-threatening asthma attacks. Exposure to sunlight, sunlamps or UV light and extreme heat, wind or cold should be avoided. Use of sunscreen with appropriate SPF of 30 or higher is required. Wear protective clothing and change to nonhormonal forms of birth control, if hormonal methods are used.

Tri-Luma® Cream contains hydroquinone, which may produce exogenous ochronosis, a gradual blue-black darkening of the skin, whose occurrence should prompt discontinuation of therapy. Tri-Luma® Cream contains the corticosteroid fluocinolone acetonide. Systemic absorption of topical corticosteroids can produce reversible hypothalamic-pituitary-adrenal (HPA) axis suppression with the potential for corticosteroid insufficiency after withdrawal of treatment.

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September 7th, 2016:

October 26, 2015:
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