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Brand Names: Cyclogest 400
Generic Name: Progesterone
What Cyclogest is and what it is
Cyclogest contains progesterone which is a natural,
female sex hormone, produced in the body. This
medicine works by adjusting the hormonal balance
within the body.
Cyclogest may be used for treating:
• pre-menstrual syndrome which often affects
women during the 7 to 10 days before their
monthly period. The symptoms of pre-menstrualsyndrome include feelings of tension, irritability,
depression, headache, breast tenderness, weight
gain and bloatedness
• post-natal depression which some women get
after their baby has been born.
Before you use
Do not use Cyclogest and tell your doctor
• have ever had any unexpected and
unexplained bleeding from your vagina which
was not due to your normal monthly period.
Check with your doctor or pharmacist
before using Cyclogest if you:
• ever had liver problems such as jaundice
(yellowing of the skin and whites of the eyes).
Pregnancy and breast-feeding
If you are pregnant, think you may be pregnant,
planning a family or breast-feeding, ask your
doctor or pharmacist for advice before using this
How to use
Always use Cyclogest exactly as your doctor has
told you. If you are not sure, check with your doctor
Do not swallow Cyclogest.
The usual dose is 200mg once a day or 400mg
twice a day by vaginal or rectal insertion.
For premenstrual tension start using Cyclogest
on day 12 or 14 of your menstrual cycle. This can
be planned and marked onto your calendar, day
1 is the first day of your monthly period, counting
forward to day 12 or 14 as advised by your doctor.
The pessary may be inserted into either the vagina
or rectum (back passage) depending upon the
following certain other conditions. You should
insert Cyclogest into the:
• vagina if you have:
− colitis (inflammation of the colon causing
frequent attacks of diarrhoea with mucous or
− problems controlling your bowel movements (faecal incontinence).
• rectum (back passage) if you have:
− a vaginal infection (discharge from your
− or often have cystitis (a burning pain on
− recently given birth
− to use a barrier method of birth control such
as a diaphragm, cap or condom. Such devices
may not work properly in the presence of the
vegetable fat from the pessary.
How to insert Cyclogest
Always wash your hands before and after inserting
To insert into the:
• Vagina - place the pessary between the lips of
the vagina and push the pessary upwards and
backwards. You may find it easier to do this if you
are lying down or squatting.
• Rectum (back passage) - gently push the
pessary into the rectum for about one inch.
Your muscles will hold the pessary in place
when it is in far enough. Squeeze your buttocks
together for a few seconds.
If you use more Cyclogest than you should
If you (or someone else) has accidentally swallowed
any of the pessaries or you use too many, contact
your nearest hospital casualty department or your
doctor immediately for advice.
If you miss a dose of Cyclogest
If you forget to insert a pessary, do so as soon as
you remember, unless it is nearly time for the next
dose. Never use two doses together. Remember to
use the remaining doses at the correct time.
Possible side effects
Like all medicines, Cyclogest can cause side effects,
although not everybody gets them.
Tell your doctor if you notice any of the following
side effects or notice any other effects not listed:
• soreness in your rectum (back passage)
• flatulence (wind).
Do not worry if you find changes in your menstrual
cycle. You may find that your monthly period will
start earlier than usual or it may be delayed.
After using Cyclogest you may notice some leakage
after the pessary has dissolved. Do not worry, this
is quite normal when using medicines that are
inserted into the vagina or rectum.
If you notice any side effects, they get worse, or if
you notice any not listed, please tell your doctor or
How to store
Keep out of the reach and sight of children.
Store below 25°C in a dry place.
Do not use Cyclogest after the expiry date stated
on the label/carton/bottle. The expiry date refers to
the last day of that month.
Medicines should not be disposed of via
wastewater or household waste. Ask your
pharmacist how to dispose of medicines no longer
required. These measures will help to protect the
What Cyclogest contains
• The active substance (the ingredient that makes
the tablets work) is progesterone. Each pessary
contains either 200mg or 400mg of the active
• The other ingredients are vegetable fat.
What Cyclogest looks like and contents of
Cyclogest are off-white pessaries.
Pack sizes are 15.
Many women suffer from a condition called
premenstrual syndrome or PMS. This is commonly
known as PMT (premenstrual tension) because of
the anxiety and bad temper often associated with
it. However, there are many other symptoms that
occur with PMS including depression, bloating and
breast tenderness. It is not just your symptoms
that decide whether you have PMS but the time at
which they are at their worst.
PMS is characterised by the symptoms that occur
during the days leading up to your period and are
then completely relieved by menstruation. The
cause of PMS is not completely understood but it
is believed to be related to the hormonal changes
that occur during the monthly cycle. Many
women obtain relief from their symptoms when
their hormonal balance is altered with a medicine
prescribed by their doctor.
Many mothers experience short-term periods of
mild depression following the birth of their baby.
This is a common condition, usually occurring
three or four days after delivery, affecting at least
half of all new mothers who may feel tearful,
overwhelmed and irritable during this time.
Support, reassurance and rest can help these
feelings to pass within a few days.
However, if the anxiety does not improve, the
mother may be developing postnatal depression.
Up to 15 per cent of new mothers develop more
severe symptoms within 12 months of their child’s
birth. Postnatal depression (PND) is characterised
by marked low mood for a more prolonged period
Though it may take several weeks or months
until a full recovery is reached, PND is a treatable
condition from which the mother will get better.
Speak to your midwife, health visitor or doctor if
you have any further questions.