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Generic name: Diosmin + Hesperidin
Brand Names: Daflon, Detralex, Arvenum 500, Alvenor, Ardium, Capiven, Elatec and Venitol
Micronized purified flavonoid fraction 500 mg (corresp to diosmin 450 mg, flavonoids expressed as hesperidin 50 mg)
Treatment of the symptoms and signs of organic and idiopathic chronic venous insufficiency of the lower limbs eg, heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
Treatment of the symptoms of acute hemorrhoidal attacks and chronic hemorrhoidal disease.
Usual Dose: Chronic Venous Insufficiency: 2 tabs daily with meals.
Chronic Hemorrhoidal Disease: 2 tabs daily with meals.
Acute Hemorrhoidal Attack: 6 tabs daily (in 2 divided doses) for 4 days, then 4 tabs daily (in 2 divided doses) for 3 days, 2 tabs thereafter.
Should be taken with food (Take at mealtimes.).
Use in pregnancy: Experimental studies have not shown any teratogenic effect in animals. In human beings, no harmful effect has so far been reported.
Use in lactation: In the absence of data concerning the diffusion into breast milk, breastfeeding is not recommended during treatment.
Each tablet contains micronized purified flavonoid fraction 500 mg corresponding to diosmin 450 mg and flavonoids expressed as hesperidin 50 mg.
Mechanism of Action
Daflon 500 mg is a phlebotonic drug and a vascular protecting agent.
The efficacy of Daflon 500 mg is accounted for by its specific action on the principal elements of venous disease.
Daflon 500 mg is phlebotonic: It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus, Daflon 500 mg decreases venous capacitance, venous distensibility and venous emptying time.
Daflon 500 mg protects the microcirculation by fighting the microcirculation-damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Daflon 500 mg normalizes capillary permeability and strengthens capillary resistance.
Daflon 500 mg acts on the lymphatic system: It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with a phlebotonic and vasculoprotective effect, explains the activity of Daflon 500 mg on CVI-associated edema.
Double-blind, placebo-controlled studies have demonstrated Daflon 500 mg's efficacy on chronic venous insufficiency. Daflon 500 mg significantly improves disabling symptoms of venous insufficiency which affect everyday active life: Heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
In addition to conventional compression therapy, Daflon 500 mg has also demonstrated to cure 3 times as many venous leg ulcers as placebo, and to accelerate their complete healing.
Daflon 500 mg is highly effective in the treatment of chronic hemorrhoidal disease. It significantly improves subjective symptoms and objective signs eg, anal discomfort, pain, redness, anal discharge, proctitis, tenesmus, pruritus, erythema and bleeding. Daflon 500 mg also significantly reduces the frequency, severity and duration of acute hemorrhoidal attacks by a chronic treatment.