Trenbolone Acetate (Tren A)
is a highly androgenic/anabolic steroid (AAS) and a potent agonist of androgen receptors which has been extensively used as a growth promoter. Tren A is a progestin and does not convert to estrogen. The effects of Trenbolone Acetate are increased weight gain, increased aggression, sweating, insomnia, increased muscle hardness, improved food conversion efficiency, decreased muscle RNA and DNA concentrations, and decreased free cathepsin D activity in muscle. The half-life of Trenbolone Acetate in circulation is 24 hours.
Dosage & administration:
- Half life: 24 hours
- Adult dose (Male)
- 50-200mg ED or EOD by intramuscular injection
- Adult dose (Female)
- 25-50mg ED or EOD by intramuscular injection
- Average Cycle Length
- 4-16 weeks following and ED or ED injection regime
- Anabolic #500
- Androgenic # 500
- Bioavailability Estimated at 100%
- CAS Name 17-Hydroxyestra-4,9,11-trien-3-one
Why Bodybuilders Take Trenbolone
The reasons bodybuilders take trenbolone is because simply taking more testosterone causes two problems:
The gains from testosterone begin to level off after a relatively short period of time.
The side effects of testosterone become increasingly severe the more you take.
When you first start taking testosterone, you gain muscle exceptionally fast for the first 8 to 12 weeks. After this initial honeymoon period, there’s a rapid drop off in gains which can only be surmounted by taking a larger dose.
The problem with taking more testosterone, though, is that you get smaller and smaller increases in muscle mass for every additional increase in dosage.
For example, let’s say you gained 14 pounds of muscle in 10 weeks from taking 600 mg of testosterone, like the people in the aforementioned study did. If you were to double your dose to 1,200 mg per week—a more typical dose used in professional bodybuilding—you might only gain another 10 pounds of muscle over the next 10 weeks.
Despite taking twice the dose, you only gained ⅔ as much muscle as you did during the previous 10 weeks.
Scientists aren’t entirely sure why this occurs, but it’s most likely due to the fact that the body becomes resistant to the effects of testosterone over time.
The second problem that occurs when someone takes more testosterone is that side effects begin to rear their head in force.
The main side effects of taking testosterone are . . .
A drop in natural testosterone levels and decreased testicle size
An increase in estrogen levels
An increased risk of acne, baldness, and excess hair growth on the face and body
The first problem is baked into all steroids.
No matter what kind of steroid you take or how you take it, your natural testosterone levels will decrease and your testicles will shrink. Period.
This occurs because your body has a complex system in place for keeping testosterone levels within a certain range.
When you artificially raise your testosterone levels by taking steroids, your body lowers your natural testosterone levels in an attempt to bring them back to normal.
Testosterone is primarily produced in the testes, and so one of the main ways the body reduces testosterone production is by reducing testicle size.
Some people think they can short-circuit this problem by only taking a small dose of testosterone—just enough to assist in building muscle but not enough to lower their natural testosterone levels.
In fact, this is the worst possible way to take steroids.
With every milligram of testosterone you inject, your body ratchets down its own testosterone production by roughly the same amount.
On average, a healthy young man will produce 6 to 8 mg of testosterone per day, or around 30 to 40 mg per week. This will generally put his natural circulating testosterone level between 264 to 916 ng of testosterone per dL of blood.
If you were to take a baby dose of 100 mg per week of testosterone, the first thing that would happen is your natural testosterone production would drop to more or less nothing in short order.
So, right away, you’ve already run into one of the worst side effects of taking steroids. And how much muscle will you build as a result of this baby dose of testosterone?
Proof of this comes from another study conducted by scientists at the Charles R. Drew University of Medicine. The researchers took 61 young men and split them into five groups:
Group one was injected with 25 mg of testosterone per week.
Group one was injected with 50 mg of testosterone per week.
Group one was injected with 125 mg of testosterone per week.
Group one was injected with 300 mg of testosterone per week.
Group one was injected with 600 mg of testosterone per week.
The researchers also gave everyone a drug that would shut down their natural testosterone production, so they could ensure any changes in their physiology were due to the steroids and not changes in their natural testosterone. (Their natural testosterone levels would have dropped rapidly anyway—this simply sped up the process).
The scientists took careful measurements of everyone’s hormone and cholesterol levels and body composition before and after the study.
Here’s how much everyone’s testosterone levels changed:
Group one’s testosterone levels were 253 ng/dL.
Group two’s testosterone levels were 306 ng/dL.
Group three’s testosterone levels were 542 ng/dL.
Group four’s testosterone levels were 1,345ng/dL.
Group five’s testosterone levels were 2,370 ng/dL.
As you can see, group one, two, and three’s testosterone levels were still well within the normal range.
Group one didn’t gain any muscle and gained 8 pounds of fat.
Group two didn’t gain any muscle and gained 6 pounds of fat.
Group three only gained 4 pounds of muscle and didn’t lose any fat.
Pretty lame results, all things considered.
Things got interesting as the dose increased, though.
Group four gained 12 pounds of muscle and lost 2 pounds of fat, and group five gained 17 pounds of muscle and lost 2 pounds of fat.
Groups three, four, and five also lost several pounds of fat, whereas groups one and two gained several pounds.
These people weren’t exercising at all, either.
This study highlights a few critical facts about steroid use:
Steroids are extremely powerful at building muscle and burning fat.
Taking a tiny dose of steroids (25 or 50 mg) not only doesn’t increase muscle mass, it also increased fat gain.
Remember that even a small dose of steroids like 25 mg is still enough to shut down your natural production of testosterone. Despite getting lackluster results, groups one, two, and three all still had to deal with low testosterone for several months after finishing the study.
This is why anyone who’s gained a substantial amount of muscle while taking steroids has taken a relatively large dose—they have to.
The second main side effect people encounter when taking steroids is an increase in estrogen levels.
Well, in men estrogen is produced by an enzyme known as aromatase, which converts a percentage of our testosterone into estrogen through a process known as aromatization.
When testosterone levels are at their normal, healthy level, estrogen levels also remain relatively low in men.
When testosterone levels are 3, 5, or 10 times their normal level, which is what happens when people take steroids, estrogen levels increase proportionally.
This can lead to a long list of feminizing effects such as gynecomastia (“man boobs”), water retention, and fat gain.
To counter these side effects, many athletes take estrogen blockers (which come with their own side effects), but this also presents a problem:
Estrogen plays an important role in muscle growth, too, and reducing it to rock bottom levels reduces the muscle-building benefits of steroids.
Specifically, estrogen . . .
Improves the body’s response to anabolic steroids by increasing the number of androgen receptors on muscle cells.
Allows you to train harder by bolstering serotonin levels, which increases your arousal, focus, and ability to push yourself in workouts.
So, how is a roider to reap the benefits of estrogen without growing man boobs and getting bloated and fat?
Trenbolone is part of the answer.
You see, another unique feature of trenbolone is that it isn’t converted into estrogen by the body—at all.
This means you could take as much trenbolone as you wanted and never run into any of the side effects of excess estrogen (though this doesn’t entirely solve the problems of excess estrogen, as you’ll learn in a moment).
Some misguided souls take only trenbolone in order to minimize their estrogen levels, but this also produces the same problems as taking estrogen blockers.
What most informed steroid users do is take testosterone and trenbolone.
The testosterone increases their testosterone levels and maintains their estrogen production (as a portion of the testosterone is converted into estrogen). The trenbolone further increases testosterone levels and muscle growth without causing an overabundance of estrogen in the body.
Of course, bodybuilders don’t inject estrogen, but they do take testosterone which also raises estrogen levels.
Summary: The reason people take trenbolone is that it’s three times more effective for building muscle than testosterone and it doesn’t increase estrogen levels, which allows them to take a higher total dose of steroids with fewer side effects.
What Are the Trenbolone Side Effects?
Trenbolone is a mixed bag.
On the one hand, the main reason many bodybuilders take it is to reduce negative side effects from taking large amounts of testosterone or other estrogen-producing steroids.
On the other hand, trenbolone comes with its own long list of side effects, some of which are just as bad or worse than simply taking more testosterone.
You’ve already learned some of the main side effects of testosterone: a drop in natural testosterone levels and testicle size, excess estrogen production, and an increased risk of acne, baldness, and excess hair growth on the face and body.
Some of these side effects also pertain to trenbolone, but let’s cover these again briefly for the sake of completeness.
First, we’ll go over the most obvious and severe side effects, and then I’ll give you a list of what else you can expect when taking this drug.
A Drop In Natural Testosterone Levels and Testicle Size
Like every other steroid, trenbolone reduces your natural testosterone levels.
Remember—this is an unavoidable, intractable, inherent side effect of all steroids, and something that can’t be reduced, modified, or changed whatsoever.
You’ll occasionally hear people say that this or that particular steroid didn’t reduce their natural testosterone levels, but in most cases they’re either lying, ignorant of their actual testosterone levels, or are taking fake or watered down steroids.
We already skimmed over the physiology at play here, but it’s worth digging deeper to fully understand why this occurs.
To understand why natural testosterone levels always drop when you consume any kind of anabolic steroid, you first have to understand how testosterone is produced in the body.
This is a fairly complex multistep process, but bare with me. Once you understand this, you’ll understand far more about how steroids work than 99% of the people out there.
As you probably know, testosterone is produced in the testes in men (and ovaries in women). When testosterone levels begin to flag, a portion of the brain known as the hypothalamus senses this, and releases a hormone called Gonadotropin-Releasing Hormone (GnRH).
Next, the pituitary gland senses the high levels of GnRH, which causes it to produce two more hormones: luteinizing hormone (LH) and follicle-stimulating hormone (FSH).
Finally, these two hormones trigger specialized cells in the testes known as Leydig cells to produce testosterone. As testosterone levels rise, the hypothalamus produces less GnRH, testosterone production decreases, and the cycle repeats itself.
Assuming someone is otherwise healthy, this system does a remarkably good job of keeping testosterone levels within a relatively narrow range.
Everything changes when you introduce anabolic steroids into the mix, though.
The massive rise in testosterone levels triggers the hypothalamus to more or less shut down GnRH production, which shuts down LH and FSH production, which shuts down testosterone production.
Over the short term (days) natural testosterone production falls to almost nothing, and over the long-term (several months), testicle size shrinks as well.
The only way to increase natural testosterone production and testicle size again is to stop taking steroids.
Even then, it takes around two to four months for natural testosterone levels and testicle size to return to where they were before steroid use.
Keep in mind that all of this applies to steroid-like drugs like SARMs and prohormones, too. These drugs indirectly raise anabolic hormone levels in the body, which has the same effect of reducing natural testosterone levels.
Trenbolone is simply a more powerful derivative of testosterone, and so you’re going to experience all of the same effects.
As trenbolone isn’t approved for human use there are very few studies of its effects in humans, and so we don’t know what effect it might have on natural testosterone levels versus other steroids.
Due to the fact that trenbolone works in more or less the same way as testosterone, chances are that the effects are similar.
Summary: Trenbolone reduces natural testosterone levels in a matter of days and testicle size in a matter of weeks, this effect persists for as long as you continue taking trenbolone, and it doesn’t resolve until several months after stopping trenbolone.